Sandra Vladimirov Sopić, PhD

Sandra was born in 1987 in Belgrade. She graduated from the Faculty of Pharmacy, University of Belgrade (FPUB), majoring in pharmacy - medical biochemistry in 2012.  In 2013, following her internship at the Center for Medical Biochemistry, Clinical Center of Serbia, she passed the professional exam. She defended her doctoral thesis "Investigation of biomarkers of cholesterol homeostasis and vitamin D metabolism in patients with colorectal cancer" in 2019.

Sandra has been employed as a researcher at the Department of Medical Biochemistry, FPUB since 2013. She became a research associate in 2020. From 2013 to 2020 she participated in a national project "Interactive role of dyslipidemia, oxidative stress and inflammation in atherosclerosis and other diseases: genetic and biochemical markers." She has also participated in the Innovation Fund-financed project: "Development of an innovative method for minimally invasive diagnostics and monitoring of congenital adrenal hyperplasia treatment (CAHInnovateD)" and the project "HIgh-density lipoprotein MetabolOMe research to improve pregnancy outcome (HI-MOM)", financed by the Science Fund of the Republic of Serbia. In addition, Sandra is a member of the project management team of the international project "CadioSCOPE - Comprehensive and personalized assessment of acute coronary syndrome by multiomic approach and artificial intelligence strategy", funded by the EU within the Horizon Europe, Marie Skłodowska-Curie Actions (MSCA) program.

Sandra's research is focused on the development, optimization and validation of GC/FID, GC/MS and HPLC-MS/MS methods for quantification of various lipid and steroid compounds in biological samples, and investigation of their biomarker potential. The main topic of her previous research has been (epi)lipidomics with special emphasis on the investigation of cholesterol and vitamin D metabolism. So far, she has authored 18 papers in domestic and international journals. During 2023, she spent 3 months as a visiting researcher at the Cardiovascular Research Unit, Department of Precision Medicine, Luxembourg Institute of Health in Luxembourg.

Sandra Vladimirov is a member of the European Association of Atherosclerosis (EAS) and the European Oxysterol Research Network (ENOR), as well as a member of three working groups within the COST action: Pan-European Network in Lipidomics and EpiLipidomics (CA19105), Bench to bedside transition for pharmacological regulation of NRF2 in noncommunicable diseases (CA20121) and AtheroNET - Network for implementing multiomics approaches in atherosclerotic cardiovascular disease prevention and research (CA21153). In addition, he is a member of the Committee of Young Researchers at the Society of Medical Biochemists of Serbia (DMBS).

• Vladimirov S, Gojkovic T, Zeljkovic A, Jelic-Ivanovic Z, Zeljkovic D, Antonic T, Trifunovic B, Spasojevic-Kalimanovska V. Can non-cholesterol sterols indicate the presence of specific dysregulation of cholesterol metabolism in patients with colorectal cancer?. Biochemical Pharmacology. 2021:114595.
  
• Antonić TD, Ardalić DČ, Vladimirov SS, Banjac GS, Cabunac PJ, Zeljković AR, Karadžov-Orlić NT, Spasojević-Kalimanovska VV, Miković ŽD, Stefanović AŽ. Cholesterol homeostasis is dysregulated in women with preeclampsia. Pol Arch Intern Med. 2021, doi: 10.20452/pamw.16144.
• Zeljković A, Ardalić D, Vekić J, Antonić T, Vladimirov S, Rizzo M, Gojković T, Ivanišević J, Mihajlović M, Vujčić S, Cabunac P. Effects of Gestational Diabetes Mellitus on Cholesterol Metabolism in Women with High-Risk Pregnancies: Possible Implications for Neonatal Outcome. Metabolites. 2022;12(10):959.
• Petkovic A, Erceg S, Munjas J, Ninic A, Vladimirov S, Davidovic A, Vukmirovic L, Milanov M, Cvijanovic D, Mitic T, Sopic M. LncRNAs as Regulators of Atherosclerotic Plaque Stability. Cells. 2023;12(14):1832.
• Zeljkovic A, Vekic J, Mihajlovic M, Gojkovic T, Vladimirov S, Zeljkovic D, Spasojevic-Kalimanovska V, Trifunovic B. Revealing the role of high-density lipoprotein in colorectal cancer. International Journal of Molecular Sciences. 2021;22:3352.
• Vladimirov S, Zeljković A, Gojković T, Miljković M, Stefanović A, Zeljković D, Trifunović B, Spasojević-Kalimanovska V. Associations of cholesterol and vitamin D metabolites with the risk for development of high grade colorectal cancer. Journal of Medical Biochemistry. 2020;39:318.
• Vladimirov S, Gojković T, Zeljković A, Jelić-Ivanović Z, Spasojević-Kalimanovska V. Determination of non-cholesterol sterols in serum and HDL fraction by LC/MS-MS: Significance of matrix-related interferences. Journal of Medical Biochemistry. 2020;39:299.
• Mihajlovic M, Gojkovic T, Vladimirov S, Miljkovic M, Stefanovic A, Vekic J, Zeljkovic D, Trifunovic B, Kotur-Stevuljevic J, Spasojevic-Kalimanovska V, Zeljkovic A. Changes in lecithin: cholesterol acyltransferase, cholesteryl ester transfer protein and paraoxonase-1 activities in patients with colorectal cancer. Clin Biochem. 2019;63:32-8.
• Gojkovic T, Vladimirov S, Spasojevic-Kalimanovska V, Zeljkovic A, Vekic J, Arsenijevic J, Djuricic I, Sobajic S, Jelic-Ivanovic Z. Preanalytical and analytical challenges in gas chromatographic determination of cholesterol synthesis and absorption markers. Clin Chim Acta. 2018;478:74-81.
• Gojkovic T, Vladimirov S, Spasojevic-Kalimanovska V, Zeljkovic A, Vekic J, Kalimanovska-Ostric D, Djuricic I, Sobajic S, Jelic-Ivanovic Z. Can non-cholesterol sterols and lipoprotein subclasses distribution predict different patterns of cholesterol metabolism and statin therapy response?. Clin Chem Lab Med (CCLM). 2017;55(3):447-57.